The Davies Lab broadly explores microbial behavior important for improving human health and well-being. Through our research, we develop a mechanistic understanding of the processes controlling the ability of microbes to engage with humans, and engineer biologics and synthetic cell-based systems to manipulate this interface.
Research is in progress in the following areas:
- Exploring the scope of peptide sequence and structural space with antimicrobial and immune modulatory action.
- Developing peptide-based inhibitors of essential bacterial functions.
- Engineering multi-functional antibodies to control microbe-microbe and microbe-host interactions.
- Studying interactions between skin, commensals, and pathogens.
- Building synthetic cell-based systems for high throughput peptide/protein screening and delivery.
- Engineering synthetic microbes to manipulate human health and performance.
- Characterizing peptides and proteins as reversible and degradable materials.