We investigate protein-based antibiotics and bacteria-host interactions. Current projects include:
Discovering synthetic peptide antibiotics
We are exploring the sequence-structure space of peptide antibiotics and how peptides with distinct antibacterial and in vivo properties are distributed across this landscape.
Developing antibacterial antibodies
We are developing single-chain antibodies that can target and/or directly kill specific bacteria. We are selecting and enhancing scaffolds to support these activities and investigating potential bacterial targets.
Characterizing bacterial secretion systems and secreted proteins
We are exploring bacterial secretion systems and secreted proteins as sources of antibacterial scaffolds and routes to control bacterial growth and host interactions.
Designing bacteria-host interactions
We are investigating and repurposing microbe-microbe and microbe-host interactions to develop bacteria that can influence human health.