We investigate approaches to control bacterial disease and to use beneficial microbes to improve human health and performance. Current projects include:
Peptide and protein antimicrobials
Peptides and proteins provide diverse and genetically encodable templates for antimicrobial discovery and engineering. We explore natural and synthetic peptides and proteins for their potential to control bacterial disease.
Host colonization and microbial interactions
Microbes colonize all parts of the human body. We investigate how bacteria colonize unique niches and how colonization can be controlled to impact our health .
Human physiology is responsive to a wide range of chemical cues. We explore the potential of bacteria to alter human response through the delivery of natural and synthetic compounds.
We develop platforms for the discovery of biologics (peptides, proteins, and antibodies) that can influence the growth and behavior of bacteria, and their ability to affect host functions.